The No. 11 USC Trojans (2-0) are set to play their first conference game as members of the Big Ten on Saturday when they travel to Ann Arbor to take on the No. 18 Michigan Wolverines (2-1) at Michigan Stadium. The Trojans are coming off a bye last week, but defeated Utah State 48-0 in their last outing. USC has been outstanding on defense under new defensive coordinator D'Anton Lynn. Michigan is looking to build off its 28-18 win over Arkansas State last week. Alex Orji is set to start at quarterback for the Wolverines.

The Trojans are 5.5-point favorites in the latest Michigan vs. USC odds via SportsLine consensus, while the over/under for total points scored is 44. USC is a -208 (risk $336 to win $100) favorite on the money line, with Michigan listed as a +170 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any USC vs. Michigan picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season WAY UP!

Now, Kaylor has locked in a confident against-the-spread pick for USC vs. Michigan in their Week 4 matchup. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Michigan vs. USC in their Week 4 matchup in Ann Arbor, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who went 107-45-2, returning $5,790 for $100 bettors, betting on college football in 2023, and find out!